Wednesday, September 17, 2008

Longer-lived Rodents Have Lower Levels Of Thyroid Hormone




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The study further strengthen the opinion that the faster an animal's metabolism, the shorter its vivacity, and vice versa, said Mario Pinto, the study's head poet. The thyroid freedom hormones that correct metabolic rate.



"Thyroid hormones be switch meter of metabolism and savour be widely implicated to wiles longevity," the author dash off. Pinto presented the study "Differential thyroid hormone pursuit in rodents with nought similar to life spans" at a gauge date Oct. 9 at Comparative Physiology 2006: Integrating Diversity. The study be carried out by means of Pinto and Rochelle Buffenstein, City College of New York.



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"Mice strain that exhibit elongated longevity tend to have lower thyroid hormone focus than shorter playing strains," the authors wrote. "Significant decline in thyroid hormone correlate fabulously with enhanced maximum lifespan." The study relate the levels of these thyroid hormones among four group of rodents with different life span: mice, guinea pigs, Damara mole-rats and with nothing on top of mole-rats. Mice live to in the order of three and a somewhat years; guinea pigs live to six years; Damara mole-rats to 15 years; and naked mole-rats to 28 years.



The animals be of different ages, but at comparable point in their life spans. For example, the mole-rats, which live 28 years, were two years infirm. The mice, which live about 3.5 years, were six months old. The study unfaltering the levels of T3 and T4 for respectively animal.



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However, because T3, levels do not deviate significantly among all the groups, further research here deplete using larger sign size (numbers of rodents in each group) is needed, Pinto said.



APS give a yawning capacity of research, artistic and assignment support and programming to further the contributions of physiology to comprehension the mechanism of diseased and full-bodied state. In 2004, APS received the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring.



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