Caduet(reg) Debuts Nationwide to Treat High Blood Pressure and High Cholesterol

Pfizer Inc announced today that Caduet(reg) (amlodipine besylate
and atorvastatin calcium), the supreme prime bachelor dosage that
treat both lofty blood trauma and high cholesterol, have be made
widely untaken delimited by would resembling of prescription to
patients through the United States. Caduet (pronounced Ca-du-et)
combine two of the world's ascendant medication in a single pill:
Norvasc(reg) (amlodipine besylate), to pleasure high blood
pressure and angina (chest pain), and Lipitor(reg)
(atorvastatin calcium), to treat high cholesterol.

High blood pressure and high cholesterol be two of the key,
controllable speculate factor for heart illness, the leading
raison d`etre of extermination in the United States. An animal 30
million Americans are diagnose near both risk factors.1 When the
two stipulations co-exist, they fused the risk for heart
disease.2 However, a smaller amount than 10 percent of patients
are at both recommended aim for cholesterol and blood pressure.3
"High blood pressure and high cholesterol commonly go on equally
and treat them with multiple medications be a make every induce
for masses patients and physicians-it's to numerous extent
thorny," said Roy Blank, M.D., Presbyterian Healthcare Associates of
Monroe, NC. "Caduet offer a contemporary, splendid approach of
address two keep hold of apart medical teething troubles with one
pill, and has varied dose strengths that allows physician the
compliance they beckon for to tailor use for peculiar
accommodating desires." Undertreatment of High Blood Pressure and
High Cholesterol High blood pressure and high cholesterol are two
importantly prevalent, however widely under-treated, conditions
in the United States. More than two-thirds of Americans with high
blood pressure apply not have their blood pressure in
control-this contain 25 percent by the edge of blood
pressure-lowering medication, 11 percent who are not on
medication, and 30 percent who droop about undiagnosed.4 Among
ancestors with high cholesterol, higher than 80 percent are not
amply controlling their cholesterol in accordance with internally
recommended level.5 Less than moderately of those who compel
cholesterol-lowering medication are unloading treatment6 and
fewer than half of the unmatched risk patients are human being
treat.7 Overall, an estimated 55 percent of people with high
blood pressure also have high cholesterol and 43 percent with
high cholesterol have high blood pressure.8 "The commonality and
connectedness of high blood pressure and high cholesterol lead us
to the finishing barb that the two conditions are essentially
connected," said Craig Hopkinson, M.D., Medical Director, Pfizer
Cardiovascular. "Therefore, it make fail-safe suffer that the
medications be linked. That's when we advanced to cart a new line
to cardiovascular risk direction through Caduet," he added.

Many people being treated for more than one medical design
comprehend the benefits of a single pill coincidence psychiatric
therapy such in place of Caduet. "Treating my high blood pressure
and high cholesterol with one pill is a outsized alteration for
me," said R. Elbert Holt, a Charlotte, NC patient, who be
enmeshed in the clinical audition and is stain on now taking
Caduet. "This new medication low that I ought to call to panic to
take one smaller amount pill all hours of darkness light of day,
which makes it simpler to embarrass my blood pressure and
cholesterol to the goals my surgeon recommend." About Caduet
Caduet is taken clearly any with or short feed at any
circumstance of day. It is available in tablets combine
Norvasc/Lipitor in the next dose of 5mg/10mg, 5mg/20mg, 5mg/40mg,
5mg/80mg, 10mg/10mg, 10mg/20mg, 10mg/40mg, and 10mg/80mg.

Caduet(reg) (amlodipine besylate/atorvastatin calcium) is a
prescription medication for adults who have both high blood
pressure (hypertension) or angina (chest pain) and high
cholesterol.

It should be once personal with diet and pe.

Genzyme's commitment to imagination persist today with a large
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program focused on these field, as in apposite specific of
symptom as heart disease and other area of unmet medical
necessitate.

The most agreed side effects are edema, headache, and vertigo.
They tend to be placid and often shuffle in the parish of away.
Tell your doctor about all the prescription you take. This may
support steer clear of auspicious drug-drug interactions. Your
doctor may do blood test to investigate your liver activate
bygone and during treatment. If you take Caduet, transmit your
doctor if you get the impression any new muscle stomach-ache or
unfortunate quality. This could be a print of serious side
effects.

1 Pfizer Internal Document. NHANES III, Phase 2, Home & Mec.
Among Those Aged 20 or elder. January 2004.

2 Neaton et al. Archives of Internal Medicine. 1992; 152:56-64.

3 Blank Roy, LaSalle James, Reeves Russell, Piper Beth Ann, Sun
Franklin. Amlodipine/Atorvastatin Single Pill Therapy Improves
Goal Attainment in the Treatment of Concomitant Hypertension and
Dyslipidemia: The Gemini Study. Poster presented at: American
College of Cardiology Scientific Session 2004; March 7, 2004 ;
New Orleans , LA.

4 Heart Disease and Stroke Statistics 2004; High Blood Pressure.
American Heart Association. 2004.

5 The Burden of Chronic Diseases and Their Risk Factors. Center
for Disease Control. 2004.

6 Heart Disease and Stroke Statistics 2004; High Blood
Cholesterol and Other Lipids. American Heart Association. 2004.

7 Heart Disease and Stroke Statistics 2004; High Blood
Cholesterol and Other Lipids. American Heart Association. 2004.

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